The use of biocatalysts in the chemical reactions is well known from centuries and the present world is moving towards using this natural method of using biomolecules, especially enzymes or whole cells, a catalyst to fasten the process of reaction. Use of biocatalysis has expanded in last few decades, and it has impacted chemical synthesis in different industries including pharmaceuticals, fine chemicals, and food. This review discusses the current status in the field of bio catalytic engineering, biocatalysts and also the use of biocatalyst to overcome the hazards caused by the use of chemical and synthetic catalysts.